By Dennis P. O'Malley (auth.)

The spleen is an organ which has different capabilities together with immunologic and hematologic. The Atlas of Spleen Pathology describes and selectively illustrates the conventional and pathologic stipulations that afflict the spleen. This awesome choice of prime quality electronic photos will materially reduction in carrying on with efforts to acknowledge, comprehend, and effectively interpret the gross and lightweight microscopic findings in spleens.

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In this case, there is a notable increase in small lymphocytes within the red pulp. T-cell large granular lymphocytic leukemia is often identified by flow cytometry of peripheral blood. Splenectomy is only rarely performed for diagnostic purposes 44 3 Lymphoid Neoplasms Fig. 109 T-cell large granular lymphocytic leukemia. In this example of T-cell large granular lymphocytic leukemia, there are many lymphocytes in the red pulp and a blurring of the borders of the white pulp. In more advanced disease, T-cell large granular lymphocytic leukemia involves the PALS regions of the spleen Fig.

In this example of angioimmunoblastic T-cell lymphoma in spleen, the red pulp is mostly uninvolved. However, the PALS region is expanded by atypical lymphoid cells with a polymorphous appearance, which are pale in comparison to the cells of the white pulp follicle (primary follicle) Fig. 120 Angioimmunoblastic T-cell lymphoma. The polymorphous cellular nature of angioimmunoblastic T-cell lymphoma in spleen. In addition to many lymphocytes, there are also admixed plasma cells. In many cases, extramedullary hematopoiesis may also be seen Fig.

130 Mycosis fungoides. High magnification of mycosis fungoides involving spleen. The abnormal lymphocytes are small in size with slightly irregular nuclei and scant cytoplasm. 15 Diffuse Large B-cell Lymphomas Fig. 132 Diffuse large B-cell lymphoma. Gross image of diffuse large B-cell lymphoma (DLBCL) in spleen. The pale, fleshy cut surface of the nodules are typical of the gross appearance of DLBCL in any site. (Image courtesy of A. ) c Fig. 133 Diffuse large B-cell lymphoma. An example of an unsectioned spleen and accessory spleen with massive involvement by DLBCL.

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Atlas of Spleen Pathology by Dennis P. O'Malley (auth.)
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