By Togas Tulandi, Morrie Gelfand

The topic of androgen therapy in reproductive elderly men and women is attracting expanding curiosity from experts in replica medication, endocrinology and first care prone, in addition to from sufferers and the media.

The first ebook to hide androgen alternative in males and ladies, Androgens and Reproductive Aging addresses the emotive subject matters of reproductive getting older, the menopause and using androgen supplementations to mitigate their results.

Edited via best specialists in reproductive medication and infertility, and boasting an all-star forged of authors, this entire textual content covers:

* androgen creation within the fit female and male

* the decline of androgen construction in the course of getting older, with the linked results on physique composition and libido

* the advantages and capability side-effects of androgen alternative therapy.

Ideal for quite a lot of clinicians and scientists attracted to reproductive getting older, the menopause, hormone substitute and androgen treatment, in addition to obstetricians, gynecologists and kin practitioners, this exact textual content is a hugely vital addition to literature within the area.

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Additional info for Androgens and Reproductive Aging

Sample text

Deaths: Leading Cases for 2002. Natl Vital Stat Rep 2005; 53:1–89. 5. Buchner DM, Wagner EH, Preventing frail health. Clin Geriatr Med 1992; 8:1–17. 6. Stuck AE, Walthert JM, Nikolaus T et al. Risk factors for functional status decline in community-living elderly people: a systematic literature review. Soc Sci Med 1999; 48:445–469. 7. Lamberts SWJ, Endocrinology and Aging. ). WB Saunders. 2003:1287–1301. 8. Horani MH, Morley JE, Hormonal fountains of youth. Clin Geriatr Med 2004; 20:275–292. qxd 26 11/4/2005 2:44 PM Page 26 ANDROGENS AND REPRODUCTIVE AGING 9.

Furthermore, testosterone can be synthesized in target tissue on demand; consequently resulting in levels of plasma testosterone which may not provide the critical information on the availability of other metabolites. DHEAS, DHEA, and androstenedione are the major sources of peripheral androgen production in women. Serum androgens may be either unbound or bound, and it is the unbound androgens that are biologically active to exert their effects on target tissue. Following secretion from the adrenal glands and ovaries, testosterone is strongly bound by sex hormone binding globulin (SHBG) in the peripheral blood such that only ∼1% of testosterone and DHT circulates freely.

Sex hormone binding globulin (SHBG) binds approximately 66% of the total serum testosterone with another significant minority being bound by other plasma proteins. It is estimated that only 1–2% of the total testosterone is bioavailable at any one time. Factors such as oral estrogen and thyroxine can increase SHBG while obesity, growth hormone, hyperinsulinemia, and glucocorticoids all decrease SHBG concentration. Measurement of a free T index would likely reflect the bioavailable concentrations of testosterone but the accuracy of the current analog assays is questionable.

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Androgens and Reproductive Aging by Togas Tulandi, Morrie Gelfand
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