By Jean-Louis Auget, N. Balakrishnan, Mounir Mesbah, Geert Molenberghs
Statistical tools became an more and more very important and fundamental a part of examine within the future health sciences. Many subtle methodologies were built for particular functions and difficulties. This self-contained entire quantity covers quite a lot of issues bearing on new statistical tools within the future health sciences, together with epidemiology, pharmacovigilance, caliber of existence, survival research, and genomics.
The ebook will serve the overall healthiness technology neighborhood in addition to practitioners, researchers, and graduate scholars in utilized chance, records, and biostatistics.
Read or Download Advances in Statistical Methods for the Health Sciences: Applications to Cancer and AIDS Studies, Genome Sequence Analysis, and Survival Analysis PDF
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Extra resources for Advances in Statistical Methods for the Health Sciences: Applications to Cancer and AIDS Studies, Genome Sequence Analysis, and Survival Analysis
Obtaining and combining raw data from prognostic studies is a long, expensive, and rather laborious process, although it oﬀers clear compensation in avoiding methodological pitfalls. 2. Identifying unpublished data is diﬃcult and time-consuming. 3. , assays) used. 4. Reported results and publications from participating groups are usually lacking in detail and laboratory and statistical methods lack consistency. 14 D. G. Altman et al. 5. Data checking and standardisation should be given particular attention and are inevitably time-consuming.
Blankenstein, M. , Beex, L. , Klijn, J. , and Foekens, J. A. (2002). Pooled analysis of prognostic impact of urokinasetype plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients, Journal of the National Cancer Institute, 94, 116–128. 13. McKibbon, K. , and Wilczynski, N. (1995). Beyond ACP Journal Club: How to harness MEDLINE for prognosis problems, ACP Journal Club, 123. A12–A14. 14. McShane, L. , Altman, D. , Taube, S. , Clark, G. M. for the Statistics Subcommittee of the NCI/EORTC Working Group on Cancer Diagnostics (2005).
7. Many data sets will beneﬁt from corrected data and extended follow-up. 8. Detailed record keeping is of primary importance. 9. Appropriateness of analyses can be ensured, including maintaining key data as continuous and applying consistent adjustment for covariates. 10. Variation in the methods of measuring ostensibly the same variable are a serious impediment to clear conclusions – consensus methods should be developed. The main advantages of collecting IPD in systematic reviews of prognostic studies are the inclusion of extended follow-up for studies that were published; inclusion of unpublished studies with reduced risk of publication bias; ability to check the data; standardised data analysis, including correct analysis of continuous variables; analysis based on time-to-event for each patient; and ability to analyse patient subgroups.
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