By Frederick W. Alt
Advances in Immunology, a normal and hugely revered e-book, offers present advancements in addition to complete stories in immunology. Articles tackle the wide variety of issues that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities. Edited and authored via the most important scientists within the box, every one quantity presents up to date details and instructions for the future.
* Contributions from best professionals * Informs and updates on all of the most up-to-date advancements within the box
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Extra resources for Advances in Immunology
Knockdown of USP7 or DUB inhibitor induced the loss of Foxp3 protein in Tregs. Therefore, Foxp3 stability may be precisely regulated by genes related in ubiquitination/ deubiquitination. 2. Th1 cells Effector CD4 + T cells such as Th1, Th2, and Th17 play an important role for protection from infection and cancer. However, excessive effector functions could lead to adverse effects such as inflammation and autoimmunity. Thus, the development and function of effector T cells are tightly regulated to maintain a balance between immune responses and tolerance.
Proteasome inhibitor, Bortezomib (Velcade), is approved by the US FDA as an anticancer drug for multiple myeloma and mantle cell lymphoma (Chen, Frezza, Schmitt, Kanwar, & Dou, 2011). Although a precise working mechanism of Bortezomib is not fully unveiled, it has clearly shown that proteasome inhibition by Bortezomib leads to apoptosis in malignant cells by upregulating proapoptotic proteins and downregulating antiapoptotic proteins. Recent reports revealed that the modulation of not only proteasome but also E3 ligase activity is critical for treating multiple myeloma.
One of the 13 FANC proteins, FANCL, contains a RING finger-like PHD domain and catalyzes monoubiquitination of FANCD2 and FANCI, which are required for cellular resistance in response to DNA damage (Moldovan & D’Andrea, 2009). , 2012). It is also demonstrated that ubiquitin-specific peptidase 1 (USP1), which functions in deubiquitination of FANCD2, implicates in regulating HSC self-renewal. , 2010). Taken together, these studies suggest that the DNA repair system mediated by FANC E3 complex is crucial for maintenance of HSC function.
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