By David McCance, Michael Maresh, David Sacks

Edited and authored via foreign experts,A useful handbook of Diabetes in being pregnant offers multi-disciplinary evidence-based assistance proper for all these taking care of ladies with pre-existing or gestational diabetes.Divided into 5 sections, the publication covers every thing from preconception to postnatal care, in addition to detailing the dangers linked to diabetic being pregnant and the long run implications for the mummy and baby:Epidemiology and pathophysiologyImpaired glucose tolerance and gestational diabetesPrepregnancy and being pregnant careComplications in pregnancyDelivery and submit supply careThis useful source comprises therapy thoughts in line with the most recent learn to make sure pregnant girls with diabetes obtain the absolute best care.

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Extra resources for A Practical Manual of Diabetes in Pregnancy (Practical Manual of Series)

Example text

Targeted disruption of the fetal IGF1, IGF2 or IGF1R gene in mice resulted in retardation of fetal growth, whereas IGF2 overexpression enhanced fetal growth. 41 The effects of IGF1 and IGF2 can be attenuated or amplified by soluble IGF-binding proteins (IGFBPs) that influence their bioavailability. In humans, the most prevalent IGFBPs in fetal plasma and tissue are the IGFBPs 1–4. 44 A decrease in IGFBPs would result in higher bioavailability of IGFs and thus, indirectly might contribute to fetal overgrowth in diabetes.

Adipocyte stress: The endoplasmic reticulum and metabolic disease. J Lipid Res 2007; 48:1905–14. 56 Muoio DM, Newgard CB. Obesity-related derangements in metabolic regulation. Annu Rev Biochem 2006;75:367–401. 25 57 Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785–9. 58 McGarry JD, Mannaerts GP, Foster DW. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.

J Clin Invest 1982;70:117–26. 16 Freemark M. Regulation of maternal metabolism by pituitary and placental hormones: roles in fetal development and metabolic programming. Horm Res 2006;65 (Suppl 3):41–9. 24 Chapter 2 17 Catalano PM, Tyzbir ED, Wolfe RR, et al. Carbohydrate metabolism during pregnancy in control subjects and women with gestational diabetes. Am J Physiol 1993;264: E60–7. 18 Hauguel S, Gilbert M, Girard J. Pregnancy-induced insulin resistance in liver and skeletal muscles of the conscious rabbit.

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A Practical Manual of Diabetes in Pregnancy (Practical by David McCance, Michael Maresh, David Sacks
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